Li (Lee) Wang

Research Interests:

1) Drug carriers with sustained release triggered by near IR Radiation with low-energy.

Although conventional chemotherapy has been successful to some extent, the main drawbacks of chemotherapy are its poor bioavailability, high-dose requirements, adverse side effects, development of multiple drug resistance, and non-specific targeting. The main aim in the development of drug delivery vehicles is to successfully address these delivery-related problems and carry drugs to the desired sites of therapeutic action while reducing adverse side effects.

​

​2)  Proton Coupled Electron Transfer:

Many natural plant colorants, such as anthocyanin, plant-derived polyphenols, Glutathione, α-Lipoic acid, Vitamin C / E are natural antioxidants, capable to protect the body from oxidative damage, and to achieve the purpose of prevention and treatment of the disease. The most common diseases, such as retinal dysfunction, cataracts, cancer, respiratory infections, infertility, and so on are related to the lack of antioxidants with nutrients. Patients with Alzheimer's disease have vitamin E and β-carotene levels as the half as that of the normal age. The low levels of vitamin A in the body can double the possibility of suffering from lung cancer. The supplementation of vitamin E and vitamin C could reduce the possibility of heart disease by half. Antioxidants also improve the body's immune and anti-infective ability. This series of biochemical reactions and plant photosynthesis reactions can easily occur at 37 °, thank to the "Proton Coupled Electron Transfer". The key question of PCET is whether protons and electrons are transferred synchronously or progressively? From the common sense, it is accepted that electrons and protons are gradually transferred, but in fact, the reaction DG for PCET is much lower than the DG for the reaction with electrons and protons gradually transferred. The reaction with gradual transfer need to pass a transient state in which the electrons or protons has been transferred to form an unstable charged intermediate. The activation energy is required for forming the activated intermediate complex. Whereas the DG of PCET is more favorable than the DG for ET or PT.

​​

Representive Publications:

​​

1. Yifeng Lan, Guojie Qin, Yanli Wei*, Li Wang*, and Chuan Dong. 2020. “Exonuclease I-assisted fluorescence aptasensor for tetrodotoxin”, Ecotoxicology and Environmental Safety, 2019, 194: 110417. 9.

2. Hongwei Zhao, Hui Han, Hengquan Yang, Li Wang⁎, “Enantiopure sulfoximines-catalyzed 1, 4-additions to 2-en-ketone”, Molecular Catalysis  2018, 455, 210–213.

3. Prateek Dongare, Brent D. B. Myron, Li Wang, David W. Thompson*, Thomas J. Meyer*, [Ru(bpy) 3 ]2+∗ Revisited. Is it Localized or Delocalized? How does it Decay?  Coord. Chem. Rev. 2017, 345, 86-107.

4. Christopher J. Gagliardia, Li Wang, Prateek Dongarea, M. Kyle Brennamana, John Papanikolasa, Thomas J. Meyer*, and David W. Thompson*, “ Direct Observation of Light-driven, Concerted Electron– Proton Transfer”, Proc Natl Acad Sci USA. 2016，113， 11106-11109.

5. Xin Wu, Xiaojuan Gong, Wenjuan Dong, Jun Ma, Jianbin Chao, Chenzhong Li, Li Wang* and Chuan Dong*,“A novel fluorescein-based colorimetric probe for Cu2+ detection”,  RSC Adv., 2016, 6, 59677–59683.

6. Li Wang, Yuming Zhao*, Reversible Dispersion and Release of Carbon Nanotubes Using Stimuli-Responsive Molecules and Polymers, Book chapter of 《Carbon Nanotubes - Current Progress of their Polymer Composites》Book editor: Mohamed Berber, InTech Publisher，ISBN 978-953-51-4689-6, 2016, 5.

7. David F. Zigler,* Zachary A. Morseth, Li Wang, Dennis L. Ashford, M. Kyle Brennaman, Erik M. Grumstrup, Erinn C. Brigham, Melissa K. Gish, Robert J. Dillon, Leila Alibabaei, Gerald J. Meyer, Thomas J. Meyer, and John M. Papanikolas* “Disentangling the Physical Processes Responsible for the Kinetic Complexity in Interfacial Electron Transfer of Excited Ru(II) Polypyridyl Dyes on TiO2”, J. Am. Chem. Soc. 2016, 138, 4426−4438.

8. Tingting Li, Zhiguang Liu, Li Wang* and Yujing Guo* “Gold nanoparticles/Orange II functionalized graphene nanohybrid based electrochemical aptasensor for label-free determination of insulin”, RSC Adv., 2016, 6, 30732–30738.

9. Yehong Zhou, Linlin Sun, Haixia Wang, Wenting Liang, Jun Yang, Li Wang*, Shaomin Shuang*, “Investigation on the uptake and release ability of b-cyclodextrin functionalized Fe3O4 magnetic nanoparticles by methylene blue”, Materials Chemistry and Physics, 2016, 170, 83-89.

10. Feifei Li, Guoli Wu, Huixia Zheng, Li Wang*, Zhengbao Zhao*, “Synthesis, colon-targeted studies and pharmacological evaluation of an anti-ulcerative colitis drug 4-Aminosalicylic acid-β-O-glucoside”, Eur. J. Med. Chem. 2016, 108, 486–494.

11. Zachary Morseth, Li Wang, Egle Puodziukynaite, Thomas J. Meyer, Kirk S. Schanze, John R. Reynolds John M. Papanikolas “Ultrafast Dynamics In Multifunctional Ru(Ii)-Loaded Polymers For Solar Energy Conversion” Acc. Chem. Res. 2015, 48 (3), 818–827.

12. Egle Puodziukynaite, Li Wang, Kirk S. Schanze, John R. Reynolds*, John M. Papanikolas*. Synthesis and Properties of Poly(Fluorene-co-Thiophene)-Based Ionic Transition-Metal Complex Polymers for Solar Energy Harvesting and Storage Applications. Polym. Chem. 2014, 5, 2363-2369.

13. Li Wang, Dennis. L Ashford, David W. Thompson, Thomas J. Meyer, John M. Papanikolas*. “Watching Photoactivation in a Ru(II) Chromophore-Catalyst Assembly on TiO2 by Ultrafast Spectroscopy”. J. Phys. Chem. C. 2013, 117, 24250-24258.

14. L. Wang, E. Puodziukynaite, E. Grumstrub, J. R. Reynolds and J. M. Papanikolas “Ultrafast Formation of a Long-Lived Charge-Separated State in a Ru-loaded Poly(3-hexylthiophene) Light-harvesting Polymer” J. Phys. Chem. Lett. 2013, 4, 2269−2273.

15. L. Wang, E. Puodziukynaite, R. Vary, E.Grumstrub, J. R. Reynolds and J. M. Papanikolas "Competition Between Ultrafast Energy Flow and Electron Transfer in a Ru(II)-Loaded Polyfluorene Light-Harvesting Polymer" J. Phys. Chem. Lett. 2012, 3, 2453-2457.  

16. L. Wang, N. Zhou, D. W. Thompson, Y. Zhao " OPE/OPV H-mers: Synthesis, Electronic properties, and Spectroscopic Responses to Binding with Transition Metal Ions", Tetrahedron, 2011, 67, 125-143.